TTF-1 regulates lung epithelial morphogenesis.

  title={TTF-1 regulates lung epithelial morphogenesis.},
  author={Parviz Minoo and Hasnah Hamdan and De-xiu Bu and David Warburton and Phillip Stepanik and Robert A Delemos},
  journal={Developmental biology},
  volume={172 2},
TTF-1 is a homeodomain transcriptional factor expressed in thyroid, lung, and parts of the brain. In vitro, TTF-1 can activate the promoter of thyroid- and pulmonary-specific genes. We postulated that TTF-1 not only is essential for the activation of tissue-specific genes, but also may directly participate in epithelial cell morphogenesis. To test this postulate, we used an antisense oligonucleotide inhibitory strategy in an in vitro model of embryonic mouse lung branching morphogenesis. This… CONTINUE READING
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