TTF-1 and PAX5 Are Frequently Expressed in Combined Merkel Cell Carcinoma.

@article{Czapiewski2016TTF1AP,
  title={TTF-1 and PAX5 Are Frequently Expressed in Combined Merkel Cell Carcinoma.},
  author={Piotr Czapiewski and Hanna I Majewska and Heinz Kutzner and Dmitry W Kazakov and Alicja Renkielska and Wojciech Biernat},
  journal={The American Journal of dermatopathology},
  year={2016},
  volume={38 7},
  pages={513-6}
}
Thyroid transcription factor-1 (TTF-1) is a marker of tumors of pulmonary and thyroid origin, and its expression practically excludes diagnosis of Merkel cell carcinoma (MCC). However, TTF-1 expression in combined MCC was recently reported. PAX5 is a marker of B-cell origin that is also expressed in most classical MCC cases; however, its expression was not described in combined MCC. The authors decided to evaluate the expression of both these markers in a group of 5 combined MCCs (2 with… CONTINUE READING
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Merkel cell carcinoma.

Hematology/oncology clinics of North America • 2012

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