TTC26/DYF13 is an intraflagellar transport protein required for transport of motility-related proteins into flagella

@inproceedings{Ishikawa2014TTC26DYF13IA,
  title={TTC26/DYF13 is an intraflagellar transport protein required for transport of motility-related proteins into flagella},
  author={Hiroaki Ishikawa and Takahiro Ide and Toshiki Yagi and Xue Jiang and Masafumi Hirono and Hiroyuki Sasaki and Haruaki Yanagisawa and Kimberly A. Wemmer and Didier Y R Stainier and Hongmin Qin and Ritsu Kamiya and Wallace F. Marshall},
  booktitle={eLife},
  year={2014}
}
Cilia/flagella are assembled and maintained by the process of intraflagellar transport (IFT), a highly conserved mechanism involving more than 20 IFT proteins. However, the functions of individual IFT proteins are mostly unclear. To help address this issue, we focused on a putative IFT protein TTC26/DYF13. Using live imaging and biochemical approaches we show that TTC26/DYF13 is an IFT complex B protein in mammalian cells and Chlamydomonas reinhardtii. Knockdown of TTC26/DYF13 in zebrafish… CONTINUE READING

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Chapter 2-Evolutionary biology of Dyneins

  • B Wickstead, K. Gull
  • In: King SM, editor. Dyneins: structure, biology…
  • 2011
Highly Influential
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