TTBK2 with EB1/3 regulates microtubule dynamics in migrating cells through KIF2A phosphorylation.

@article{Watanabe2015TTBK2WE,
  title={TTBK2 with EB1/3 regulates microtubule dynamics in migrating cells through KIF2A phosphorylation.},
  author={Takayuki Watanabe and Mai Kakeno and Toshinori Matsui and Ikuko Sugiyama and Nariko Arimura and Kenji Matsuzawa and Aya Shirahige and Fumiyoshi Ishidate and Tomoki Nishioka and Shinichiro Taya and Mikio Hoshino and Kozo Kaibuchi},
  journal={The Journal of cell biology},
  year={2015},
  volume={210 5},
  pages={737-51}
}
Microtubules (MTs) play critical roles in various cellular events, including cell migration. End-binding proteins (EBs) accumulate at the ends of growing MTs and regulate MT end dynamics by recruiting other plus end-tracking proteins (+TIPs). However, how EBs contribute to MT dynamics through +TIPs remains elusive. We focused on tau-tubulin kinase 2 (TTBK2) as an EB1/3-binding kinase and confirmed that TTBK2 acted as a +TIP. We identified MT-depolymerizing kinesin KIF2A as a novel substrate of… CONTINUE READING