TSSC3 overexpression reduces stemness and induces apoptosis of osteosarcoma tumor-initiating cells

@article{Huang2012TSSC3OR,
  title={TSSC3 overexpression reduces stemness and induces apoptosis of osteosarcoma tumor-initiating cells},
  author={Yusheng Huang and Huanzi Dai and Qiao-nan Guo},
  journal={Apoptosis},
  year={2012},
  volume={17},
  pages={749-761}
}
Osteosarcoma (OS) is the most common primary bone tumor in children and adolescents, typically presenting with poor prognosis. Recent studies suggested that tumor initiating cells (T-ICs) drive tumor formation and relapse or metastasis and are relatively resistant to cell death induced by conventional chemo- and radiotherapies. Therefore, the poor prognosis of OS appears to be associated with T-ICs. Here, we enriched T-ICs in OS cell lines and evaluated whether the imprinted gene TSSC3 (tumor… CONTINUE READING
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