TSSC3 overexpression associates with growth inhibition, apoptosis induction and enhances chemotherapeutic effects in human osteosarcoma.

@article{Dai2012TSSC3OA,
  title={TSSC3 overexpression associates with growth inhibition, apoptosis induction and enhances chemotherapeutic effects in human osteosarcoma.},
  author={Huanzi Dai and Yusheng Huang and Yi Li and Gang Meng and Yongqiang Wang and Qiao-nan Guo},
  journal={Carcinogenesis},
  year={2012},
  volume={33 1},
  pages={
          30-40
        }
}
Loss of expression of TSSC3, an apoptosis-related imprinted gene, has been reported in several cases of malignant tumors. However, the roles and mechanisms of TSSC3 in human osteosarcoma remain to be defined. In this study, we found TSSC3 to be downregulated during osteosarcoma transformation and progression in osteosarcoma cell lines and tissues. The SaOS2 cell line was used to further evaluate the precise role of TSSC3 in osteosarcoma development. Overexpression of TSSC3 markedly reduced cell… CONTINUE READING

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