TSPYL2 is an essential component of the REST/NRSF transcriptional complex for TGFβ signaling activation

@article{Epping2015TSPYL2IA,
  title={TSPYL2 is an essential component of the REST/NRSF transcriptional complex for TGFβ signaling activation},
  author={Mirjam T. Epping and Andrea Lunardi and Daphna Nachmani and Mireia Castillo-Martin and Tin Htwe Thin and Carlos Cordon-Cardo and Pier Paolo Pandolfi},
  journal={Cell Death and Differentiation},
  year={2015},
  volume={22},
  pages={1353-1362}
}
REST/NRSF is a transcriptional repressor of neuronal genes that has been implicated in development and cancer. In epithelial tissues, REST acts as a tumor suppressor and in breast cancer, loss of REST is associated with disease recurrence and poor prognosis. Here, we identify TSPYL2 (also known as CDA1 and DENTT) as a novel component of the REST protein complex. We show that REST and TSPYL2 are regulators of TGFβ signaling and that cell-cycle arrest induced by TGFβ requires both REST and TSPYL2… CONTINUE READING
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