TSPY potentiates cell proliferation and tumorigenesis by promoting cell cycle progression in HeLa and NIH3T3 cells

@article{Oram2006TSPYPC,
  title={TSPY potentiates cell proliferation and tumorigenesis by promoting cell cycle progression in HeLa and NIH3T3 cells},
  author={Shane W Oram and Xing Xing Liu and Tin Lap Lee and Wai-Yee Chan and Yun-Fai Chris Lau},
  journal={BMC Cancer},
  year={2006},
  volume={6},
  pages={154 - 154}
}
TSPY is a repeated gene mapped to the critical region harboring the gonadoblastoma locus on the Y chromosome (GBY), the only oncogenic locus on this male-specific chromosome. Elevated levels of TSPY have been observed in gonadoblastoma specimens and a variety of other tumor tissues, including testicular germ cell tumors, prostate cancer, melanoma, and liver cancer. TSPY contains a SET/NAP domain that is present in a family of cyclin B and/or histone binding proteins represented by the… CONTINUE READING
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