TSPO mutations in rats and a human polymorphism impair the rate of steroid synthesis

  title={TSPO mutations in rats and a human polymorphism impair the rate of steroid synthesis},
  author={David R. Owen and Jinjiang Fan and Enrico Campioli and Sathvika Venugopal and Andrew S Midzak and Edward Daly and Aline Harlay and Leeyah Issop and Vincenzo Libri and Dimitra Kalogiannopoulou and Eduardo Oliver and Enrique Gallego-Colon and Alessandro Colasanti and Les Huson and Eugenii A. Rabiner and Puvan Suppiah and Charles Essagian and Paul M. Matthews and Vassilios Papadopoulos},
  booktitle={The Biochemical journal},
The 18 kDa translocator protein (TSPO) is a ubiquitous conserved outer mitochondrial membrane protein implicated in numerous cell and tissue functions, including steroid hormone biosynthesis, respiration, cell proliferation, and apoptosis. TSPO binds with high affinity to cholesterol and numerous compounds, is expressed at high levels in steroid-synthesizing tissues, and mediates cholesterol import into mitochondria, which is the rate-limiting step in steroid formation. In humans, the rs6971… CONTINUE READING
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Positron emission tomography and functional characterization of a complete PBR / TSPO knockout

V. Papadopoulos
Nat . Commun . • 2014

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