TSPAN12 Is a Norrin Co-receptor that Amplifies Frizzled4 Ligand Selectivity and Signaling.

@article{Lai2017TSPAN12IA,
  title={TSPAN12 Is a Norrin Co-receptor that Amplifies Frizzled4 Ligand Selectivity and Signaling.},
  author={Maria B Lai and Chi Zhang and Jianli Shi and Verity Johnson and Lavan Khandan and John H Mcvey and Michael W Klymkowsky and Zhe Chen and Harald J Junge},
  journal={Cell reports},
  year={2017},
  volume={19 13},
  pages={
          2809-2822
        }
}
Accessory proteins in Frizzled (FZD) receptor complexes are thought to determine ligand selectivity and signaling amplitude. Genetic evidence indicates that specific combinations of accessory proteins and ligands mediate vascular β-catenin signaling in different CNS structures. In the retina, the tetraspanin TSPAN12 and the ligand norrin (NDP) mediate angiogenesis, and both genes are linked to familial exudative vitreoretinopathy (FEVR), yet the molecular function of TSPAN12 remains poorly… CONTINUE READING