TSP50, a possible protease in human testes, is activated in breast cancer epithelial cells.

@article{Shan2002TSP50AP,
  title={TSP50, a possible protease in human testes, is activated in breast cancer epithelial cells.},
  author={Jidong Shan and Liming Yuan and Qianxun Xiao and Nicholas Chiorazzi and Daniel R. Budman and Saul Teichberg and Hao-peng Xu},
  journal={Cancer research},
  year={2002},
  volume={62 1},
  pages={290-4}
}
Initial studies have identified TSP50 as a human testes-specific gene that is demethylated in breast cancer. In this study, we will present new data related to the TSP50 gene. We have found that the TSP50 gene product shares a similar enzymatic structure with many serine proteases. However, the most critical catalytic site, serine, has been replaced by threonine. Western analysis revealed that in human testes, the TSP50 antibody detected two closely positioned protein bands whose estimated… CONTINUE READING
27 Citations
20 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 27 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 20 references

Isolation of a novel gene, TSP50, by a hypomethylated DNA fragment in human breast cancer

  • L. M. Yuan, J. D. Shan, +5 authors H. P. Xu
  • Cancer Res.,
  • 1999
Highly Influential
4 Excerpts

Similar Papers

Loading similar papers…