TSLP produced by keratinocytes promotes allergen sensitization through skin and thereby triggers atopic march in mice.

@article{LeyvaCastillo2013TSLPPB,
  title={TSLP produced by keratinocytes promotes allergen sensitization through skin and thereby triggers atopic march in mice.},
  author={Juan Manuel Leyva-Castillo and Pierre Hener and Hua Jiang and Mei Li},
  journal={The Journal of investigative dermatology},
  year={2013},
  volume={133 1},
  pages={154-63}
}
Atopic dermatitis often precedes the development of asthma, a phenomenon known as "atopic march". An important role of allergen sensitization developed through barrier-defective skin has been recognized in the onset of atopic march; however, the underlying mechanism remains poorly understood. In this study, we use an experimental atopic march mouse model, in which the sensitization to allergen is achieved through barrier-impaired skin, followed by allergen challenge in the airway. By using… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 42 extracted citations

[Skin microbiota and atopic dermatitis: toward new therapeutic options?].

Annales de dermatologie et de venereologie • 2015
View 6 Excerpts
Highly Influenced

Thymic stromal lymphopoietin drives the development of IL-13+ Th2 cells

Proceedings of the National Academy of Sciences of the United States of America • 2018

References

Publications referenced by this paper.
Showing 1-10 of 40 references

Epidermal barrier dysfunction in atopic dermatitis.

The Journal of investigative dermatology • 2009
View 9 Excerpts
Highly Influenced

Atopic dermatitis.

The New England journal of medicine • 2008
View 8 Excerpts
Highly Influenced

TSLP-activated dendritic cells induce an inflammatory T helper type 2 cell response through OX40 ligand

The Journal of experimental medicine • 2005
View 5 Excerpts
Highly Influenced

Barrier dysfunction caused by environmental proteases in the pathogenesis of allergic diseases.

Allergology international : official journal of the Japanese Society of Allergology • 2011
View 1 Excerpt

Similar Papers

Loading similar papers…