TSLP Inhibitors for Asthma: Current Status and Future Prospects

@article{Matera2020TSLPIF,
  title={TSLP Inhibitors for Asthma: Current Status and Future Prospects},
  author={Maria Gabriella Matera and Paola Rogliani and Luigino Calzetta and Mario Cazzola},
  journal={Drugs},
  year={2020},
  volume={80},
  pages={449-458}
}
Thymic stromal lymphopoietin (TSLP) is an allarmin cytokine whose importance in human asthma has been repeatedly documented. Accordingly, targeting of TSLP and TSLP-mediated signalling is considered as an attractive therapeutic strategy to asthma. Tezepelumab, which is the first-in-class anti-TSLP monoclonal antibodies (mAb), is a fully human IgG2λ mAb that binds human TSLP, prevents interaction with its receptor and, consequently, inhibits multiple downstream inflammatory pathways. Because of… 

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