TSLC1 expression discriminates cutaneous melanomas from dysplastic nevi.

@article{You2012TSLC1ED,
  title={TSLC1 expression discriminates cutaneous melanomas from dysplastic nevi.},
  author={Y. -M. You and Shu Huai Wang and Jin Feng Zhang and Shu Yun Zheng},
  journal={Melanoma research},
  year={2012},
  volume={22 6},
  pages={430-5}
}
Cutaneous melanoma is a malignant tumor of melanocytes that causes the majority of skin cancer-related deaths. However, sometimes, discrimination between dysplastic nevi and early melanomas is difficult, even for experienced pathologists. Besides histology, the silencing of tumor suppressor genes aids in the diagnosis of melanoma. We have shown previously that tumor suppressor in lung cancer 1 (TSLC1) is a tumor suppressor gene, and its silencing through aberrant promoter methylation is… CONTINUE READING