TSH restores a summer phenotype in photoinhibited mammals via the RF-amides RFRP3 and kisspeptin.

@article{Klosen2013TSHRA,
  title={TSH restores a summer phenotype in photoinhibited mammals via the RF-amides RFRP3 and kisspeptin.},
  author={Paul Klosen and M. Sebert and Kamontip Rasri and Marie-Pierre Laran-Chich and Val{\'e}rie Simonneaux},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2013},
  volume={27 7},
  pages={
          2677-86
        }
}
In mammals, melatonin is the pivotal messenger synchronizing biological functions, notably reproductive activity, with annual daylength changes. Recently, two major findings clarified melatonin's mode of action. First, melatonin controls the production of thyroid stimulating hormone (TSH) by the pars tuberalis of the adenohypophysis. This TSH regulates local thyroid hormone availability in the mediobasal hypothalamus. Second, the RF-amides kisspeptin and RFRP-3, recently discovered regulators… CONTINUE READING
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