TSH controls Ref-1 nuclear translocation in thyroid cells.

  title={TSH controls Ref-1 nuclear translocation in thyroid cells.},
  author={Gianluca Tell and Lucia Pellizzari and Carlo Pucillo and Fabio Puglisi and Daniela Cesselli and Mark R Kelley and Carla di Loreto and Giuseppe Damante},
  journal={Journal of molecular endocrinology},
  volume={24 3},
Ref-1 (called also APE) is a bifunctional protein playing a role in a large variety of cell functions. It is a major member of the DNA base excision repair system. Moreover, through reduction of cysteine residues, Ref-1 controls the activity of several transcription factors. It has been previously demonstrated that TSH up-regulates Ref-1 gene expression in thyroid cells. By using the rat FRTL-5 cell line, we demonstrate that TSH controls Ref-1 intracellular localization. Western blot… CONTINUE READING
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