TSH-R expression and cytokine profile in orbital tissue of active vs. inactive Graves' ophthalmopathy patients.

@article{Wakelkamp2003TSHREA,
  title={TSH-R expression and cytokine profile in orbital tissue of active vs. inactive Graves' ophthalmopathy patients.},
  author={Iris M. M. J. Wakelkamp and Onno Bakker and Lelio Baldeschi and Wilmar Maarten Wiersinga and Mark F. Prummel},
  journal={Clinical endocrinology},
  year={2003},
  volume={58 3},
  pages={280-7}
}
OBJECTIVE From in vitro studies using cultures of orbital fibroblasts, it has become clear that cytokines play an important role in the orbital inflammation in Graves' ophthalmopathy (GO). Orbital fibroblasts seem to be the key target cells of the autoimmune attack, and they are able to express the TSH receptor (TSH-R). In vivo data on the presence of… CONTINUE READING