TSG-6 inhibits osteoclast activity via an autocrine mechanism and is functionally synergistic with osteoprotegerin.

@article{Mahoney2011TSG6IO,
  title={TSG-6 inhibits osteoclast activity via an autocrine mechanism and is functionally synergistic with osteoprotegerin.},
  author={David J. Mahoney and Catherine Swales and Nicholas A Athanasou and Michele Bombardieri and Costantino Pitzalis and Karolina Kliskey and Mohammed Rashid Sharif and Anthony J Day and Caroline M. Milner and A Faraji Sabokbar},
  journal={Arthritis and rheumatism},
  year={2011},
  volume={63 4},
  pages={
          1034-43
        }
}
OBJECTIVE TSG-6 (the product of tumor necrosis factor [TNF]-stimulated gene 6) has a potent inhibitory effect on RANKL-mediated bone erosion. The aim of this study was to compare the activity of TSG-6 with that of osteoprotegerin (OPG) and to investigate its role as an autocrine modulator of cytokine-mediated osteoclast formation/activation. We also determined TSG-6 expression in inflammatory joint disease. METHODS The effects of TSG-6, OPG, and the inflammation mediators TNFα, interleukin-1… CONTINUE READING
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