TSG-6 controls transcription and activation of matrix metalloproteinase 1 in conjunctivochalasis.

@article{Guo2012TSG6CT,
  title={TSG-6 controls transcription and activation of matrix metalloproteinase 1 in conjunctivochalasis.},
  author={Ping Guo and Su-zhen Zhang and Hua He and Yingting Zhu and Scheffer C. G. Tseng},
  journal={Investigative ophthalmology & visual science},
  year={2012},
  volume={53 3},
  pages={1372-80}
}
PURPOSE To investigate the role of anti-inflammatory TSG-6 in controlling MMP-1 and MMP-3, which have been shown to be upregulated in conjunctivochalasis (CCh). METHODS Immunostaining of TSG-6 was compared between normal and CCh conjunctiva and Tenon's capsule. Second cultures of normal and CCh fibroblasts were transfected with or without TSG-6 siRNA and… CONTINUE READING