TSG-6 Regulates Bone Remodeling through Inhibition of Osteoblastogenesis and Osteoclast Activation*S⃞

@inproceedings{Mahoney2008TSG6RB,
  title={TSG-6 Regulates Bone Remodeling through Inhibition of Osteoblastogenesis
 and Osteoclast
 Activation*S⃞},
  author={David J. Mahoney and Katalin Mikecz and Tariq Javid Ali and Guillaume Mabilleau and Dafna Benayahu and Anna Plaas and Caroline M. Milner and Anthony J Day and Afsaneh Sabokbar},
  booktitle={The Journal of biological chemistry},
  year={2008}
}
TSG-6 is an inflammation-induced protein that is produced at pathological sites, including arthritic joints. In animal models of arthritis, TSG-6 protects against joint damage; this has been attributed to its inhibitory effects on neutrophil migration and plasmin activity. Here we investigated whether TSG-6 can directly influence bone erosion. Our data reveal that TSG-6 inhibits RANKL-induced osteoclast differentiation/activation from human and murine precursor cells, where elevated dentine… CONTINUE READING
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