TSC22D2 interacts with PKM2 and inhibits cell growth in colorectal cancer.

@article{Liang2016TSC22D2IW,
  title={TSC22D2 interacts with PKM2 and inhibits cell growth in colorectal cancer.},
  author={F. Liang and Qiao Li and Xiayu Li and Z. Li and Zhaojian Gong and H. Deng and B. Xiang and M. Zhou and Xiaoling Li and Guiyuan Li and Z. Zeng and W. Xiong},
  journal={International journal of oncology},
  year={2016},
  volume={49 3},
  pages={
          1046-56
        }
}
We previously identified TSC22D2 (transforming growth factor β-stimulated clone 22 domain family, member 2) as a novel cancer-associated gene in a rare multi-cancer family. However, its role in tumor development remains completely unknown. In this study, we found that TSC22D2 was significantly downregulated in colorectal cancer (CRC) and that TSC22D2 overexpression inhibited cell growth. Using a co-immunoprecipitation (co-IP) assay combined with mass spectrometry analysis to identify TSC22D2… Expand
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