TSC1 stabilizes TSC2 by inhibiting the interaction between TSC2 and the HERC1 ubiquitin ligase.

@article{ChongKopera2006TSC1ST,
  title={TSC1 stabilizes TSC2 by inhibiting the interaction between TSC2 and the HERC1 ubiquitin ligase.},
  author={Huira Chong-Kopera and Ken Inoki and Yong Li and Tianqing Zhu and Francesc R. Garcia-Gonzalo and Jos{\'e} L. A. Rosa and Kun Liang Guan},
  journal={The Journal of biological chemistry},
  year={2006},
  volume={281 13},
  pages={8313-6}
}
Tuberous sclerosis complex (TSC) is an autosomal dominant disease characterized by hamartoma formation in various organs. Two genes responsible for the disease, TSC1 and TSC2, have been identified. The TSC1 and TSC2 proteins, also called hamartin and tuberin, respectively, have been shown to regulate cell growth through inhibition of the mammalian target of rapamycin pathway. TSC1 is known to stabilize TSC2 by forming a complex with TSC2, which is a GTPase-activating protein for the Rheb small… CONTINUE READING
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