TRiC subunits enhance BDNF axonal transport and rescue striatal atrophy in Huntington's disease.

Abstract

Corticostriatal atrophy is a cardinal manifestation of Huntington's disease (HD). However, the mechanism(s) by which mutant huntingtin (mHTT) protein contributes to the degeneration of the corticostriatal circuit is not well understood. We recreated the corticostriatal circuit in microfluidic chambers, pairing cortical and striatal neurons from the BACHD… (More)
DOI: 10.1073/pnas.1603020113

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