Corpus ID: 29979539

TRYPANOCIDAL BISBENZYLISOQUINBLINE ALKALOIDS ARE INHIBITORS OF TRYPANOTHIONE REDUCTASE

@inproceedings{bisbcnylisoquinolinc2002TRYPANOCIDALBA,
  title={TRYPANOCIDAL BISBENZYLISOQUINBLINE ALKALOIDS ARE INHIBITORS OF TRYPANOTHIONE REDUCTASE},
  author={Elcvcn bisbcnylisoquinolinc},
  year={2002}
}
against Chagas discasc,' was iilso studied. Six BBIQ nlkaloids (anlioqiiinc, ccpliaranlhinc, daphi1oline, liniacine, cycleaninc and (-) curine) displiiycd it 50'%1 IclhaI conccntration ( LCF,J against T. c r u 5 of less than IOOpM. Daphnoline and culinc, with LC5cl values of IOpM. are attractive ror further investigation ils potential anti-Chagasic drugs. Kinetic analyses suggested the BBIQ alkaloids are mixed inhibitors of TR. These coiiipounds arc reasonably potent inhibitors of TR; Lhe best… Expand
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SHOWING 1-9 OF 9 REFERENCES
"J."
Bioor,y. Mctl. C'lrcwr
  • 1996
I3ick. I.R.C. il110 [I91 Docampo
  • Parosilol. Toduy
  • 1996
Crithidia l.ir,scicx/nln n:L'i~~/f0//ii0ii~ Ret/w(rr.vc, rtl 1.70 ØI Rc
  • 1995
BiOChe/lli,Yft'J~, 31, I 1793-I 1800
  • 1992
J . l1'77/77UJ70-151 I;:icrm;iii. C.I-I.,&ivvidcs, S
  • 1991
Ctm
  • ./. Ckw7.. 65, 343-347.
  • 1987
111: Me//). E /~L J~/ I I
  • 1979
A.1-I. and Datiglas, í<.T. ( I 992). ßiochP/77. .I.. 286. 9-I I