• Corpus ID: 29979539

TRYPANOCIDAL BISBENZYLISOQUINBLINE ALKALOIDS ARE INHIBITORS OF TRYPANOTHIONE REDUCTASE

@inproceedings{bisbcnylisoquinolinc2002TRYPANOCIDALBA,
  title={TRYPANOCIDAL BISBENZYLISOQUINBLINE ALKALOIDS ARE INHIBITORS OF TRYPANOTHIONE REDUCTASE},
  author={Elcvcn bisbcnylisoquinolinc},
  year={2002}
}
against Chagas discasc,' was iilso studied. Six BBIQ nlkaloids (anlioqiiinc, ccpliaranlhinc, daphi1oline, liniacine, cycleaninc and (-) curine) displiiycd it 50'%1 IclhaI conccntration ( LCF,J against T. c r u 5 of less than IOOpM. Daphnoline and culinc, with LC5cl values of IOpM. are attractive ror further investigation ils potential anti-Chagasic drugs. Kinetic analyses suggested the BBIQ alkaloids are mixed inhibitors of TR. These coiiipounds arc reasonably potent inhibitors of TR; Lhe best… 
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