TRPV4 is associated with central rather than nephrogenic osmoregulation

@article{Janas2016TRPV4IA,
  title={TRPV4 is associated with central rather than nephrogenic osmoregulation},
  author={Sylvie Janas and François Seghers and Olivier Schakman and Mohammad Alsady and Peter M T Deen and Joris Vriens and Fadel Tissir and Bernd Nilius and Johannes Loffing and Philippe Gailly and Olivier Devuyst},
  journal={Pfl{\"u}gers Archiv - European Journal of Physiology},
  year={2016},
  volume={468},
  pages={1595-1607}
}
TRPV4 is a polymodal cation channel expressed in osmosensitive neurons of the hypothalamus and in the mammalian nephron. The segmental distribution and role(s) of TRPV4 in osmoregulation remain debated. We investigated the renal distribution pattern of TRPV4 and the functional consequences of its disruption in mouse models. Using qPCR on microdissected segments, immunohistochemistry, and a LacZ reporter mouse, we found that TRPV4 is abundantly expressed in the proximal tubule, the late distal… CONTINUE READING
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References

Publications referenced by this paper.
SHOWING 1-10 OF 44 REFERENCES

PKD1 haploinsufficiency causes a syndrome of inappropriate antidiuresis in mice.

  • Journal of the American Society of Nephrology : JASN
  • 2007
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

Altered central TRPV4 expression and lipid raft association related to inappropriate vasopressin secretion in cirrhotic rats.

  • American journal of physiology. Regulatory, integrative and comparative physiology
  • 2009
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

Abnormal osmotic regulation in trpv4-/- mice.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2003
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

Vanilloid receptorrelated osmotically activated channel (VR-OAC), a candidate vertebrate osmoreceptor

LiedtkeW, Y Choe, +6 authors S Heller
  • Cell
  • 2000
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

Collecting duct principal cell transport processes and their regulation.

  • Clinical journal of the American Society of Nephrology : CJASN
  • 2015
VIEW 1 EXCERPT

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