TRPV4 activates autonomic and behavioural warmth-defence responses in Wistar rats.

@article{Vizin2015TRPV4AA,
  title={TRPV4 activates autonomic and behavioural warmth-defence responses in Wistar rats.},
  author={Robson Cristiano Lillo Vizin and Carolina da Silveira Scarpellini and D{\'e}bora T Ishikawa and G M Correa and Clovis Wesley Oliveira de Souza and Luciane H Gargaglioni and D C Carrettiero and K{\^e}nia C B{\'i}cego and Maria Camila Almeida},
  journal={Acta physiologica},
  year={2015},
  volume={214 2},
  pages={275-89}
}
AIM In this study, we aimed at investigating the involvement of the warmth-sensitive channel - TRPV4 (in vitro sensitive to temperatures in the range of approx. 24-34 °C) - on the thermoregulatory mechanisms in rats. METHODS We treated rats with a chemical selective agonist (RN-1747) and two antagonists (RN-1734 and HC-067047) of the TRPV4 channel and measured core body temperature, metabolism, heat loss index and preferred ambient temperature. RESULTS Our data revealed that chemical… CONTINUE READING

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