TRPV4 Mechanosensitive Ion Channel Regulates Lipopolysaccharide-Stimulated Macrophage Phagocytosis.

@article{Scheraga2016TRPV4MI,
  title={TRPV4 Mechanosensitive Ion Channel Regulates Lipopolysaccharide-Stimulated Macrophage Phagocytosis.},
  author={Rachel G Scheraga and Susamma Abraham and Kathryn A. Niese and Brian D Southern and Lisa M Grove and Robert Duncan Hite and Christine McDonald and Thomas A Hamilton and Mitchell A Olman},
  journal={Journal of immunology},
  year={2016},
  volume={196 1},
  pages={
          428-36
        }
}
Macrophage phagocytosis of particles and pathogens is an essential aspect of innate host defense. Phagocytic function requires cytoskeletal rearrangements that depend on the interaction between macrophage surface receptors, particulates/pathogens, and the extracellular matrix. In the present study we determine the role of a mechanosensitive ion channel, transient receptor potential vanilloid 4 (TRPV4), in integrating the LPS and matrix stiffness signals to control macrophage phenotypic change… CONTINUE READING

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