TRPV4, TRPC1, and TRPP2 assemble to form a flow-sensitive heteromeric channel.

@article{Du2014TRPV4TA,
  title={TRPV4, TRPC1, and TRPP2 assemble to form a flow-sensitive heteromeric channel.},
  author={Juan Du and Xin Ma and Bing Shen and Yu Huang and Lutz Birnbaumer and Xiaoqiang Yao},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2014},
  volume={28 11},
  pages={
          4677-85
        }
}
Transient receptor potential (TRP) channels, a superfamily of ion channels, can be divided into 7 subfamilies, including TRPV, TRPC, TRPP, and 4 others. Functional TRP channels are tetrameric complexes consisting of 4 pore-forming subunits. The purpose of this study was to explore the heteromerization of TRP subunits crossing different TRP subfamilies. Two-step coimmunoprecipitation (co-IP) and fluorescence resonance energy transfer (FRET) were used to determine the interaction of the different… CONTINUE READING

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