TRPV1b, a functional human vanilloid receptor splice variant.

  title={TRPV1b, a functional human vanilloid receptor splice variant.},
  author={Gang Lu and Dorian Henderson and Lieju Liu and Peter H. Reinhart and Sidney Arthur Simon},
  journal={Molecular pharmacology},
  volume={67 4},
Transient receptor potential (TRP) genes encode a family of related ion-channel subunits. This family consists of cation-selective, calcium-permeable channels that include a group of vanilloid receptor channels (TRPV) implicated in pain and inflammation. These channels are activated by diverse stimuli, including capsaicin, lipids, membrane deformation, heat, and protons. Six members of the TRPV family have been identified that differ predominantly in their activation properties. However, in… CONTINUE READING