TRPV1 mediates the uterine capsaicin-induced NMDA NR2B-dependent cross-organ reflex sensitization in anesthetized rats.

@article{Peng2008TRPV1MT,
  title={TRPV1 mediates the uterine capsaicin-induced NMDA NR2B-dependent cross-organ reflex sensitization in anesthetized rats.},
  author={Hsien-Yu Peng and Hung-Ming Chang and Shin-Da Lee and Pei-chen Huang and Gin-Den Chen and Cheng-Hung Lai and Cheng-Yuan Lai and Chun-Hsien Chiu and K R Tung and T Lin},
  journal={American journal of physiology. Renal physiology},
  year={2008},
  volume={295 5},
  pages={F1324-35}
}
Spinal cord-mediated cross-organ sensitization between the uterus and the lower urinary tract may underlie the high concurrence of obstetrical/gynecological inflammation and chronic pelvic pain syndrome characterized by urogenital pain. However, the neural pathway and the neurotransmitters involved are still unknown. We tested the hypothesis that the excitation of capsaicin-sensitive primary afferent fibers arising from the uterus through the stimulation of transient receptor potential… CONTINUE READING

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