TRPV1-mediated UCP2 upregulation ameliorates hyperglycemia-induced endothelial dysfunction

@inproceedings{Sun2013TRPV1mediatedUU,
  title={TRPV1-mediated UCP2 upregulation ameliorates hyperglycemia-induced endothelial dysfunction},
  author={Jing Sun and Yunfei Pu and Peijian Wang and Sijiao Chen and Yu Zhao and Chan Liu and Qianhui Shang and Zhiming Zhu and Daoyan Liu},
  booktitle={Cardiovascular Diabetology},
  year={2013}
}
BackgroundDiabetic cardiovascular complications are characterised by oxidative stress-induced endothelial dysfunction. Uncoupling protein 2 (UCP2) is a regulator of mitochondrial reactive oxygen species (ROS) generation and can antagonise oxidative stress, but approaches that enhance the activity of UCP2 to inhibit ROS are scarce. Our previous studies show that activation of transient receptor potential vanilloid 1 (TRPV1) by capsaicin can prevent cardiometabolic disorders. In this study, we… CONTINUE READING

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