TRPV1 in Brain Is Involved in Acetaminophen-Induced Antinociception

  title={TRPV1 in Brain Is Involved in Acetaminophen-Induced Antinociception},
  author={Christophe Mallet and David Andr{\'e} Barri{\`e}re and Anna Ermund and Bo A. G. J{\"o}nsson and Alain Eschalier and Peter M Zygmunt and Edward D H{\"o}gest{\"a}tt},
  booktitle={PloS one},
BACKGROUND Acetaminophen, the major active metabolite of acetanilide in man, has become one of the most popular over-the-counter analgesic and antipyretic agents, consumed by millions of people daily. However, its mechanism of action is still a matter of debate. We have previously shown that acetaminophen is further metabolized to N-(4-hydroxyphenyl)-5Z,8Z,11Z,14Z -eicosatetraenamide (AM404) by fatty acid amide hydrolase (FAAH) in the rat and mouse brain and that this metabolite is a potent… CONTINUE READING
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