TRPV1 gene knockout impairs preconditioning protection against myocardial injury in isolated perfused hearts in mice.

@article{Zhong2007TRPV1GK,
  title={TRPV1 gene knockout impairs preconditioning protection against myocardial injury in isolated perfused hearts in mice.},
  author={Beihua Zhong and Donna H. Wang},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2007},
  volume={293 3},
  pages={H1791-8}
}
Although the transient receptor potential vanilloid type 1 (TRPV1)-containing afferent nerve fibers are widely distributed in the heart, the relationship between TRPV1 function and cardiac ischemic preconditioning (PC) has not been well defined. Using TRPV1 knockout mice (TRPV1(-/-)), we studied the role of TRPV1 in PC-induced myocardial protection. Hearts of gene-targeted TRPV1-null mutant (TRPV1(-/-)) or wild-type (WT) mice were Langendorffly perfused in the presence or absence of CGRP(8-37… CONTINUE READING

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