TRPV1 and PLC Participate in Histamine H4 Receptor-Induced Itch.

@article{Jian2016TRPV1AP,
  title={TRPV1 and PLC Participate in Histamine H4 Receptor-Induced Itch.},
  author={Tunyu Jian and Niuniu Yang and Yan Yang and Chan Zhu and Xiaolin Yuan and Guang Yu and Changming Wang and Zhongli Wang and Hao Shi and Min Tang and Qian He and Lei Lan and Guanyi Wu and Zongxiang Tang},
  journal={Neural plasticity},
  year={2016},
  volume={2016},
  pages={1682972}
}
Histamine H4 receptor has been confirmed to play a role in evoking peripheral pruritus. However, the ionic and intracellular signaling mechanism of activation of H4 receptor on the dorsal root ganglion (DRG) neurons is still unknown. By using cell culture and calcium imaging, we studied the underlying mechanism of activation of H4 receptor on the DRG neuron. Immepip dihydrobromide (immepip)-a histamine H4 receptor special agonist under cutaneous injection-obviously induced itch behavior of mice… CONTINUE READING

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