TRPV1 and CB1 receptor‐mediated effects of the endovanilloid/endocannabinoid N‐arachidonoyl‐dopamine on primary afferent fibre and spinal cord neuronal responses in the rat

@article{Sagar2004TRPV1AC,
  title={TRPV1 and CB1 receptor‐mediated effects of the endovanilloid/endocannabinoid N‐arachidonoyl‐dopamine on primary afferent fibre and spinal cord neuronal responses in the rat},
  author={Devi Rani Sagar and Paul A. Smith and Paul J. Millns and Darren Smart and David A. Kendall and Victoria Chapman},
  journal={European Journal of Neuroscience},
  year={2004},
  volume={20}
}
N‐arachidonoyl‐dopamine (NADA) is an endogenous ligand at TRPV1 and CB1 receptors, which are expressed on primary afferent nociceptors. The aim of this study was to determine contributions of proposed pronociceptive TRPV1 and antinociceptive CB1 receptors to effects of peripheral NADA on primary afferent fibre function. Effects of NADA on primary afferent nociceptor function, determined by whole cell patch clamp and calcium imaging studies of adult dorsal root ganglion (DRG) neurons, were… 
Enhancement of spontaneous and heat-evoked activity in spinal nociceptive neurons by the endovanilloid/endocannabinoid N-arachidonoyldopamine (NADA).
TLDR
The results suggest that the enhanced responses of spinal nociceptive neurons likely underlie the behavioral thermal hyperalgesia and implicate a possible pain-sensitizing role of endogenous NADA mediated by TRPV1 in the periphery.
Inhibitory effects of CB1 and CB2 receptor agonists on responses of DRG neurons and dorsal horn neurons in neuropathic rats
TLDR
At the level of the spinal cord, CB2 receptors have inhibitory effects in neuropathic, but not sham‐operated rats suggesting that spinal CB2 may be an important analgesic target.
N-Arachidonoyl-Dopamine Tunes Synaptic Transmission onto Dopaminergic Neurons by Activating both Cannabinoid and Vanilloid Receptors
TLDR
A significant role exerted by the endocannabinoid/endovanilloid NADA in the regulation of synaptic transmission to DA neurons of the SNpc is demonstrated, highlighting a key function of the EMT transporter in promoting the stimulation of TRPV1 or CB1-R, thus favoring facilitation or inhibition of glutamate synaptic release.
The cannabinoid WIN 55,212-2 inhibits transient receptor potential vanilloid 1 (TRPV1) and evokes peripheral antihyperalgesia via calcineurin.
TLDR
The hypothesis that certain cannabinoids directly inhibit peripheral capsaicin-sensitive nociceptive neurons by dephosphorylating and desensitizing transient receptor potential vanilloid 1 (TRPV1) via a calcium calcineurin-dependent mechanism is tested.
Effects of inhibition of fatty acid amide hydrolase vs. the anandamide membrane transporter on TRPV1‐mediated calcium responses in adult DRG neurons; the role of CB1 receptors
The aim of the present study was to investigate the relationship between TRPV1 stimulation and endocannabinoid‐driven CB1 receptor‐mediated inhibition of activity in adult rat dorsal root ganglion
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