TRPV1 and CB1 receptor‐mediated effects of the endovanilloid/endocannabinoid N‐arachidonoyl‐dopamine on primary afferent fibre and spinal cord neuronal responses in the rat

@article{Sagar2004TRPV1AC,
  title={TRPV1 and CB1 receptor‐mediated effects of the endovanilloid/endocannabinoid N‐arachidonoyl‐dopamine on primary afferent fibre and spinal cord neuronal responses in the rat},
  author={D. R. Sagar and P. Smith and P. Millns and D. Smart and D. Kendall and V. Chapman},
  journal={European Journal of Neuroscience},
  year={2004},
  volume={20}
}
N‐arachidonoyl‐dopamine (NADA) is an endogenous ligand at TRPV1 and CB1 receptors, which are expressed on primary afferent nociceptors. The aim of this study was to determine contributions of proposed pronociceptive TRPV1 and antinociceptive CB1 receptors to effects of peripheral NADA on primary afferent fibre function. Effects of NADA on primary afferent nociceptor function, determined by whole cell patch clamp and calcium imaging studies of adult dorsal root ganglion (DRG) neurons, were… Expand
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