TRPV1 activation prevents high-salt diet-induced nocturnal hypertension in mice

@article{Hao2011TRPV1AP,
  title={TRPV1 activation prevents high-salt diet-induced nocturnal hypertension in mice},
  author={Xinzhong Hao and Jing Chen and Zhidan Luo and Hongbo He and Hao Yu and Liqun Ma and Shuangtao Ma and Tianqi Zhu and Daoyan Liu and Zhiming Zhu},
  journal={Pfl{\"u}gers Archiv - European Journal of Physiology},
  year={2011},
  volume={461},
  pages={345-353}
}
High dietary salt-caused hypertension is associated with increasing reactive oxygen species generation and reduced nitric oxide (NO) bioavailability. Transient receptor potential vanilloid type 1 (TRPV1), a specific receptor for capsaicin, is proposed to be involved in Dahl salt-sensitive hypertension, as determined in acute or short-term experiments. However, it remains unknown whether activation of TRPV1 by dietary capsaicin could prevent the vascular oxidative stress and hypertension induced… CONTINUE READING
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Nitric oxide and oxidative stress in vascular disease

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