TRPMLs: in sickness and in health.

  title={TRPMLs: in sickness and in health.},
  author={Rosa Puertollano and Kirill I Kiselyov},
  journal={American journal of physiology. Renal physiology},
  volume={296 6},
TRPML1, TRPML2 and TRPML3 belong to the mucolipin family of the TRP superfamily of ion channels. The founding member of this family, TRPML1, was cloned during the search for the genetic determinants of the lysosomal storage disease mucolipidosis type IV (MLIV). Mucolipins are predominantly expressed within the endocytic pathway, where they appear to regulate membrane traffic and/or degradation. The physiology of mucolipins raises some of the most interesting questions of modern cell biology… CONTINUE READING
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