TRPML: transporters of metals in lysosomes essential for cell survival?

  title={TRPML: transporters of metals in lysosomes essential for cell survival?},
  author={Kirill K Kiselyov and Grace A Colletti and Austen L Terwilliger and Kathleen Ketchum and Christopher W P Lyons and John Ryan Quinn and Shmuel Muallem},
  journal={Cell calcium},
  volume={50 3},
Key aspects of lysosomal function are affected by the ionic content of the lysosomal lumen and, therefore, by the ion permeability in the lysosomal membrane. Such functions include regulation of lysosomal acidification, a critical process in delivery and activation of the lysosomal enzymes, release of metals from lysosomes into the cytoplasm and the Ca(2+)-dependent component of membrane fusion events in the endocytic pathway. While the basic mechanisms of lysosomal acidification have been… CONTINUE READING
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