TRPM8 ion channel is aberrantly expressed and required for preventing replicative senescence in pancreatic adenocarcinoma: potential role of TRPM8 as a biomarker and target.

Abstract

Pancreatic adenocarcinoma is mostly fatal and generally resistant to conventional treatments, such that effective therapies with tolerable side effects are desperately needed. Ion channels including the transient receptor potential (TRP) channels have been implicated in human malignancies, but their roles in pancreatic cancer were mostly unknown. Recent… (More)
DOI: 10.4161/cbt.20079

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Cite this paper

@article{Yee2012TRPM8IC, title={TRPM8 ion channel is aberrantly expressed and required for preventing replicative senescence in pancreatic adenocarcinoma: potential role of TRPM8 as a biomarker and target.}, author={Nelson S. Yee and Robert D. Brown and Min Sun Lee and Weiqiang Zhou and Chris Jensen and Henning Gerke and Rosemary K. Yee}, journal={Cancer biology & therapy}, year={2012}, volume={13 8}, pages={592-9} }