TRPM8 activation attenuates inflammatory responses in mouse models of colitis.

  title={TRPM8 activation attenuates inflammatory responses in mouse models of colitis.},
  author={Rithwik Ramachandran and Eric D. Hyun and Liena Zhao and Tamia K. Lapointe and Kevin E. Chapman and Christina L. Hirota and Subrata Ghosh and D D Mckemy and Nathalie Vergnolle and Paul L. Beck and Christophe Altier and Morley D Hollenberg},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={110 18},
Transient Receptor Potential Melastatin-8 (TRPM8), a recently identified member of the transient receptor potential (TRP) family of ion channels, is activated by mild cooling and by chemical compounds such as the supercooling agent, icilin. Since cooling, possibly involving TRPM8 stimulation, diminishes injury-induced peripheral inflammation, we hypothesized that TRPM8 activation may also attenuate systemic inflammation. We thus studied the involvement of TRPM8 in regulating colonic… CONTINUE READING


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A novel role for TRPM 8 in visceral afferent function

  • AM Harrington
  • 2011

A novel role for TRPM8 in visceral afferent function. Pain 152(7):1459–1468

  • AM Harrington
  • 2011
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