TRPM8: from cold to cancer, peppermint to pain.

  title={TRPM8: from cold to cancer, peppermint to pain.},
  author={Wendy M. Knowlton and D D Mckemy},
  journal={Current pharmaceutical biotechnology},
  volume={12 1},
Temperature perception is vital for cellular and metabolic homeostasis, avoidance, and survival. In the primary afferent nerve terminal, select members of the transient receptor potential (TRP) family of ion channels reside and convert thermal stimuli into neuronal activity. The cold and menthol receptor, TRPM8, is the predominant thermoceptor for cellular and behavioral responses to cold temperatures. Remarkably, this single molecular sensor of cold, that responds at a discrete thermal… CONTINUE READING