TRPM7 regulates myosin IIA filament stability and protein localization by heavy chain phosphorylation.

@article{Clark2008TRPM7RM,
  title={TRPM7 regulates myosin IIA filament stability and protein localization by heavy chain phosphorylation.},
  author={Kristopher Clark and Jeroen Middelbeek and Edwin Lasonder and Natalya G. Dulyaninova and Nick A. Morrice and Alexey G. Ryazanov and Anne R. Bresnick and Carl G. Figdor and Frank N van Leeuwen},
  journal={Journal of molecular biology},
  year={2008},
  volume={378 4},
  pages={
          790-803
        }
}
Deregulation of myosin II-based contractility contributes to the pathogenesis of human diseases, such as cancer, which underscores the necessity for tight spatial and temporal control of myosin II activity. Recently, we demonstrated that activation of the mammalian alpha-kinase TRPM7 inhibits myosin II-based contractility in a Ca(2+)- and kinase-dependent manner. However, the molecular mechanism is poorly defined. Here, we demonstrate that TRPM7 phosphorylates the COOH-termini of both mouse and… CONTINUE READING
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