TRPM7 regulates cell adhesion by controlling the calcium-dependent protease calpain.

  title={TRPM7 regulates cell adhesion by controlling the calcium-dependent protease calpain.},
  author={Li-Ting Su and Maria A Agapito and Mingjiang Li and William T. N. Simonson and Anna Huttenlocher and Raymond Habas and Lixia Yue and Loren W Runnels},
  journal={The Journal of biological chemistry},
  volume={281 16},
m-Calpain is a protease implicated in the control of cell adhesion through focal adhesion disassembly. The mechanism by which the enzyme is spatially and temporally controlled is not well understood, particularly because the dependence of calpain on calcium exceeds the submicromolar concentrations normally observed in cells. Here we show that the channel kinase TRPM7 localizes to peripheral adhesion complexes with m-calpain, where it regulates cell adhesion by controlling the activity of the… CONTINUE READING

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