TRPM7 promotes the metastatic process in human nasopharyngeal carcinoma.

  title={TRPM7 promotes the metastatic process in human nasopharyngeal carcinoma.},
  author={Jian-Peng Chen and Jun Wang and Y P Luan and Cai-xia Wang and Wen-Huan Li and Jin-biao Zhang and Dan Sha and Rong Shen and Yan-Gang Cui and Zheng Zhang and Liming Zhang and Wei-Bo Wang},
  journal={Cancer letters},
  volume={356 2 Pt B},
Our study observed the relationship between transient receptor potential melastatin 7 (TRPM7) expression and the metastatic process of nasopharyngeal carcinoma (NPC). We found that TRPM7 was overexpressed in 102 out of 206 (49.5%) human NPC cases and was significantly associated with clinical stage and lymphatic and distant metastasis. The results suggested that TRPM7 promotes NPC cell migration and invasion in vitro. Further, TRPM7 was correlated with poor clinical outcome and was an… CONTINUE READING

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