TRPM7 is overexpressed in human IBD-related and sporadic colorectal cancer and correlates with tumor grade.

@article{Pugliese2020TRPM7IO,
  title={TRPM7 is overexpressed in human IBD-related and sporadic colorectal cancer and correlates with tumor grade.},
  author={D. Pugliese and A. Armuzzi and F. Castri and R. Benvenuto and A. Mangoni and L. Guidi and A. Gasbarrini and G. Rapaccini and F. Wolf and Valentina Trapani},
  journal={Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver},
  year={2020}
}
  • D. Pugliese, A. Armuzzi, +7 authors Valentina Trapani
  • Published 2020
  • Medicine
  • Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
  • BACKGROUND Inflammatory bowel disease (IBD) predisposes to colorectal cancer (CRC) with some specific features that distinguish it from sporadic CRC. Magnesium (Mg) homeostasis is severely compromised in IBD patients, which may affect both inflammation and tumor development. Efficient transcellular Mg transport in intestinal cells depends on the transient receptor potential melastatin (TRPM) channels type 6 and 7, but their expression has never been investigated in the context of IBD-related… CONTINUE READING

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