TRPM7 Provides an Ion Channel Mechanism for Cellular Entry of Trace Metal Ions

@article{MonteilhZoller2003TRPM7PA,
  title={TRPM7 Provides an Ion Channel Mechanism for Cellular Entry of Trace Metal Ions},
  author={Mahealani K. Monteilh-Zoller and Meredith C. Hermosura and Monica J. S. Nadler and Andrew M Scharenberg and Reinhold Penner and Andrea Fleig},
  journal={The Journal of General Physiology},
  year={2003},
  volume={121},
  pages={49 - 60}
}
Trace metal ions such as Zn(2+), Fe(2+), Cu(2+), Mn(2+), and Co(2+) are required cofactors for many essential cellular enzymes, yet little is known about the mechanisms through which they enter into cells. We have shown previously that the widely expressed ion channel TRPM7 (LTRPC7, ChaK1, TRP-PLIK) functions as a Ca(2+)- and Mg(2+)-permeable cation channel, whose activity is regulated by intracellular Mg(2+) and Mg(2+).ATP and have designated native TRPM7-mediated currents as magnesium… CONTINUE READING
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