TRPM7 Is Required for Normal Synapse Density, Learning, and Memory at Different Developmental Stages.

@article{Liu2018TRPM7IR,
  title={TRPM7 Is Required for Normal Synapse Density, Learning, and Memory at Different Developmental Stages.},
  author={Yuqiang Liu and Cui Ming Chen and Yunlong Liu and Wenxin Li and Zhihong Wang and Qifeng Sun and Hang Zhou and Xiangjun Chen and Yongchun Yu and Yun Wang and Nashat Abumaria},
  journal={Cell reports},
  year={2018},
  volume={23 12},
  pages={
          3480-3491
        }
}
The TRPM7 chanzyme contributes to several biological and pathological processes in different tissues. However, its role in the CNS under physiological conditions remains unclear. Here, we show that TRPM7 knockdown in hippocampal neurons reduces structural synapse density. The synapse density is rescued by the α-kinase domain in the C terminus but not by the… CONTINUE READING