TRPM4 impacts on Ca2+ signals during agonist-induced insulin secretion in pancreatic beta-cells.

@article{Marigo2009TRPM4IO,
  title={TRPM4 impacts on Ca2+ signals during agonist-induced insulin secretion in pancreatic beta-cells.},
  author={Valeria Marigo and Kerri Courville and W H Hsu and Ji Ming Feng and Henry Kam-Hong Cheng},
  journal={Molecular and cellular endocrinology},
  year={2009},
  volume={299 2},
  pages={194-203}
}
TRPM4 is a Ca(2+)-activated non-selective cation (CAN) channel that functions in cell depolarization, which is important for Ca(2+) influx and insulin secretion in pancreatic beta-cells. We investigated TRPM4 expression and function in the beta-cell lines HIT-T15 (hamster), RINm5F (rat), beta-TC3 (mouse), MIN-6 (mouse) and the alpha-cell line INR1G9 (hamster). By RT-PCR, we identified TRPM4 transcripts in alpha- and beta-cells. Patch-clamp recordings with increasing Ca(2+) concentrations… CONTINUE READING