TRPM2-mediated Ca2+ influx induces chemokine production in monocytes that aggravates inflammatory neutrophil infiltration

@article{Yamamoto2008TRPM2mediatedCI,
  title={TRPM2-mediated Ca2+ influx induces chemokine production in monocytes that aggravates inflammatory neutrophil infiltration},
  author={Shinichiro Yamamoto and Shunichi Shimizu and Shigeki Kiyonaka and Nobuaki Takahashi and Teruaki Wajima and Yuji Hara and Takaharu Negoro and Toshihito Hiroi and Yuji Kiuchi and Takaharu Okada and Shuji Kaneko and Ingo Lange and Andrea Fleig and Reinhold Penner and Miyuki Nishi and Hiroshi Takeshima and Yasuo Mori},
  journal={Nature Medicine},
  year={2008},
  volume={14},
  pages={738-747}
}
Reactive oxygen species (ROS) induce chemokines responsible for the recruitment of inflammatory cells to sites of injury or infection. Here we show that the plasma membrane Ca2+-permeable channel TRPM2 controls ROS-induced chemokine production in monocytes. In human U937 monocytes, hydrogen peroxide (H2O2) evokes Ca2+ influx through TRPM2 to activate Ca2+-dependent tyrosine kinase Pyk2 and amplify Erk signaling via Ras GTPase. This elicits nuclear translocation of nuclear factor-κB essential… CONTINUE READING
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