TRPM2 functions as a lysosomal Ca2+-release channel in beta cells.

  title={TRPM2 functions as a lysosomal Ca2+-release channel in beta cells.},
  author={Ingo Lange and Shinichiro Yamamoto and Santiago Partida-Sanchez and Yasuo Mori and Andrea Fleig and Reinhold Penner},
  journal={Science signaling},
  volume={2 71},
TRPM2 is a Ca2+-permeable cation channel that is specifically activated by adenosine diphosphoribose (ADPR). Channel activation in the plasma membrane leads to Ca2+ influx and has been linked to apoptotic mechanisms. The primary agonist, ADPR, is produced both extra- and intracellularly and causes increases in intracellular calcium concentration ([Ca2+]i), but the mechanisms involved are not understood. Using short interfering RNA and a knockout mouse, we report that TRPM2, in addition to its… CONTINUE READING
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